The current version of metakit seems unable to enable the python binding
support. I first tried using the metakit-2.4.9.2.ebuild in gentoo's
portage tree but was not enabling the python use flag. I explicitly set
that flag in the commandline with no change. I emerged the
metakit-2.4.7.37 version without fault. I checked the ebuild files for
errors & changes... only differences were for sed and portage
improvements. I then tried using your install instructions & a
separately downloaded tar.gz but got the same results as seen below
brian@big_squirt metakit-2.4.9.2 $ cd builds
brian@big_squirt builds $ ../unix/configure --enable-python
checking for Python configuration... not enabled
checking for Tcl headers... not enabled
checking for building with threads... no (default)
checking for C++ compiler default output... a.out
..<snip>
[email protected]

I found it! You forgot to update the install docs. Change
To build the Mk4py extension on Unix, change the configure to:
% ../unix/configure --enable-python
to
To build the Mk4py extension on Unix, change the configure to:
% ../unix/configure --with-python
as you changed --enable-python to --with-python. I will submit the
subsequent ebuild bug to gentoo for correction.
The install failed during the build, but it looks to be ebuild related
<snip>
ranlib /var/tmp/portage/metakit-2.4.9.2/image//usr/lib/libmk4.a
chmod 644 /var/tmp/portage/metakit-2.4.9.2/image//usr/lib/libmk4.a
libtool: install: warning: remember to run `libtool --finish /usr/lib'
/bin/sh ./libtool --mode=install /bin/install -c Mk4py.so
/var/tmp/portage/metakit-2.4.9.2/image//usr/lib/python2.2/site-packages
/bin/install -c Mk4py.so
/var/tmp/portage/metakit-2.4.9.2/image//usr/lib/python2.2/site-packages/bin/install:
cannot create regular file
`/var/tmp/portage/metakit-2.4.9.2/image//usr/lib/python2.2/site-packages':
No such file or directory
make: *** [install-python] Error 1
!!! ERROR: dev-db/metakit-2.4.9.2 failed.
!!! Function src_install, Line 44, Exitcode 2
!!! (no error message)
</snip>
[email protected]

I've updated the README, thank you.